Full automatic liquid transfer workstation under the COVID-19

01

Why does large-scale nucleic acid testing require a fully automated pipette workstation?

A more effective way to deal with large-scale outbreaks of infectious diseases is to use high-throughput nucleic acid testing technology that is faster, more accurate, and more automated. By detecting the nucleic acid sequence of pathogens, rapid diagnosis can be achieved, achieving a shorter detection window period. Traditional methods often rely on manual processing, which is time-consuming and difficult to standardize. More importantly, there are significant safety risks for testing personnel, and the application of automated pipetting workstations perfectly solves this problem.

The fully automatic liquid handling workstation is an automated liquid handling platform system that can replace traditional pipetting tools in sample analysis, automatically completing high-precision liquid processing tasks such as gradient dilution, pipetting, and mixing liquids. In clinical laboratories, the ALH platform is mainly used for sample preparation and extraction, and can be combined with analytical instruments, Realize efficient ***** detection of target objects.

Its high throughput processing capability can greatly improve detection efficiency, and automated operations avoid manual errors and cross contamination issues. It has two main applications in the nucleic acid detection process: one is to combine magnetic bead separation technology for high-throughput nucleic acid extraction; For example: Vitae 100 fully automatic nucleic acid extraction and purification instrument; The second is to construct an automated PCR system by setting up a reasonable disk surface; For example, the Vitae 100 fully automated PCR system construction system is essentially a pipette workstation, but their functions are not the same.

02

The core of liquid transfer workstation: trace liquid processing technology

Micro liquid processing technology, precise temperature control technology, automation control technology, and aerosol pollution prevention technology are all difficulties that need to be overcome in product production design, and the most crucial one is precise micro liquid processing technology. If the pipetting workstation does not pursue the precision of pipetting, it cannot be called a good product. How much labor can automation replace and how much cost can be saved, It is not a fundamental indicator of its performance. Safety, efficiency, and ***** are the key indicators of its performance.

Especially in nucleic acid testing experiments where there is a significant difference in liquid specificity, a wide range of pipetting ranges, and cross contamination is highly likely to occur, a small error can affect the accuracy of the results.

The trace liquid processing technology applied to automated nucleic acid detection systems should have both accuracy and safety characteristics, and should also be suitable for the special liquid characteristics of various samples and reagents, which poses great challenges to the development of liquid processing equipment. Mastering micro pipetting technology is a prerequisite for achieving automation of nucleic acid processing systems. Currently, the vast majority of fully automated nucleic acid purification workstations are based on pipetting platforms and expand experimental functions through integration and expansion to meet various needs of biochemical experiments or clinical testing.

03

The application of liquid transfer workstation

Biological reagents (various lipid reagents, enzyme solutions, buffers) and biological samples (blood, urine, saliva)