Mastering the Precision of Nano Upgrades and Realizing Innovative Development of Handheld Digital Pipettes

Pipettes can be divided into manual pipettes and electric pipettes based on whether they are manually operated or not; Divide fixed pipettes and adjustable pipettes based on whether the range is adjustable; Divide into single channel, 8 channel, 12 channel, and 96 channel workstations according to the discharged channels; According to the sterilization situation, it can be divided into half tube sterilization and whole tube sterilization. At present, with the continuous innovation of pipetting technology, handheld and electric pipettes are increasingly widely used. They can significantly improve the degree of pipetting and optimize experimental procedures, and have become powerful assistants in laboratories. The manipulation of liquid reagents is one of the fundamental operations in commonly used scientific research applications in laboratories. The pipette is currently a widely used portable liquid manipulation instrument. It is based on the principle of pneumatic piston for liquid suction and separation. Generally speaking, experimenters need to perform hundreds or thousands of pipetting tasks every day. It is essential to choose a high-performance pipette. Objectively speaking, the comfort, accuracy, safety, and durability of the pipette are all factors that users consider when choosing equipment. For the vast majority of users, it is also quite difficult to test product performance before purchasing****** Pipetting is a prerequisite for obtaining reproducible experimental results. Choosing a high-quality, professionally maintained and calibrated pipette, as well as a suitable high-quality suction head, is essential to achieve ******* accuracy. In order to achieve a high level of accuracy, a pipette with smaller pipetting force, suction head installation force, and suction head ejection force should be selected. But far from here, the experience of pipetting and laboratory management standards also directly affect the ******* of pipetting. Therefore, professional technical personnel, standardized operating procedures, and scientific laboratory operation systems cannot be ignored. The development of quality economy is accelerating day by day, and the development of pipette technology is constantly emerging. Recently, Associate Professor Li Baoqing from the Laboratory of Micro and Nano Engineering at the School of Engineering Science, University of Science and Technology of China, and Professor Pan Tingrui from the University of California, Davis, proposed and implemented a liquid transfer technology with nano upgrade accuracy. This technology combines ordinary pipette technology with microfluidic printing technology, utilizing microfluidic chips to generate nanoliter volume droplets in a controllable manner. With a single droplet as a smaller unit, it achieves the absorption and distribution of nanoliter precision liquids. It is reported that this device can be widely used in various high-precision liquid manipulation experiments. For example, using this device, different concentrations of reagents can be directly diluted to replace the previous method of continuously diluting to generate concentration gradients. This not only simplifies the operation and saves expensive reagents, but more importantly, avoids significant errors in the continuous dilution process. Looking at the market competition pattern, imported high-quality brands such as Aarhus, Sedolis, and Mettler Toledo still occupy the vast majority of the market share in the pipette market. To achieve breakthrough development in domestic pipettes, long-term exploration is needed in terms of technology research and development, application expansion, and industrial scale development.