As the main market for DNA synthesizers, the Chinese DNA synthesizer industry may accelerate its development

The development of biology, especially genetic technology, began in Europe and America, which stimulated the development of DNA synthesizers in Europe and America, making them the main production areas of synthesizers worldwide.

Synthetic biology is the third biotechnology revolution following the discovery of DNA double helix and the implementation of genomics by the Human Genome Project. DNA synthesis technology is one of the core technologies in synthetic biology, widely used in various fields such as protein modification and life sciences, such as nucleic acid drugs, enzyme engineering, gene therapy, etc. The principles of DNA synthesis mainly include chemical and biological methods. Among them, chemical methods, especially the solid-phase synthesis of phosphorite triesters, are relatively mature and widely used.

The DNA synthesizer is the core equipment for achieving automation and standardization of the DNA synthesis process. This instrument can be used to synthesize a more diverse range of DNA/RNA oligonucleotide fragments (long and ultra long chain primer fragment synthesis, fluorescence labeling and special modification primer synthesis, milligram and gram scale primer synthesis, siRNA and modified RNA synthesis, etc.), and specific chemical modifications and modifications can be carried out, including the introduction of molecular probes and special modified bases.

The DNA synthesizer is mainly used for DNA synthesis and is an important instrument for biological research and development. The development of biology, especially genetic technology, began in Europe and America, which stimulated the development of DNA synthesizers in Europe and America, making them the main production areas of synthesizers worldwide. Although genetic science in China developed relatively late, its development speed is relatively fast. In addition, commercial DNA synthesis has low profits, high pollution, and certain toxicity of raw materials. Therefore, a large amount of DNA synthesis in Europe and America is outsourced to developing countries and regions such as China, making China an important global market for DNA synthesizers.

According to the "2022 Global and China DNA Synthesizer Industry Deep Research Report" released by Xinsijie, although the global mid to high end DNA synthesizers are mainly controlled by a few companies from countries such as Germany and the United States, and the industry concentration is relatively high, most of their markets are mainly located in China.

Low flux DNA synthesizers are mainly used in various laboratories. Although the laboratory synthesis scale is relatively small, experimental personnel often have high requirements for the experimental environment, equipment, materials, etc. in order to ensure the effectiveness of the results. Therefore, they often use low flux DNA synthesizers with better performance. However, in the field of low flux DNA synthesizers, due to the relatively late development and production time in China, there are significant differences in quality and performance compared to imported products. Therefore, the low flux DNA synthesizers used in domestic laboratories are mostly K&A and Dr Oligo and other imported brands.

Commercial synthesis enterprises mainly rely on high-throughput DNA synthesizers, which have relatively high demand and procurement volume. With the development of local technology, domestic products occupy an increasingly important position in the field of such DNA synthesizers. However, in the field of low throughput DNA synthesizers, due to the high quality and performance requirements of users, China is almost in a blank stage.

Analysts from the New World of Thought believe that in the future, although the development of China's instrument and equipment industry will continue, China's research and development of DNA will be in line with